Laboratory of Cellular and Molecular Neurobiology

      There are three lines of research in our laboratory to study cellular and molecular approaches:

    Role of gangliosides in the development and regeneration of the nervous system.

    This line is aimed at studying the role of gangliosides in normal development of the nervous system and functional recovery after injury. Gangliosides constitute an important group of carbohydrates of the cell membrane and have been involved in various cellular processes in the developing nervous system and in the adult.

    Recent studies have demonstrated that systemic administration of gangliosides in animals can influence favorably to the recovery of nerve damage, both central and peripheral.

    In previous studies describe the role of ganglioside 9-0-acetylated processes in cell migration and axon growth. We demonstrate that in the developing nervous system, these molecules exhibit a selective distribution, raising the possibility of being involved in processes such as the establishment of projections. In the adult, these gangliosides are present in subsystems that have plasticity, such as the olfactory system and neurogenic regions where new neurons are generated. Such substances may therefore be important in establishing agents specific connections during development and regeneration of nervous system injury. One line of research in progress at the Laboratory aims to investigate the mechanisms by which these gangliosides exert such functions.

    Role of nitric oxide during development of the nervous system:

    Another ongoing project is to study the involvement of nitric oxide in the developing nervous system. Several recent studies suggest that nitric oxide was involved in the establishment and refinement of projections axon sprouts during nervous system development and regeneration processes in these projections. Our goal is to investigate the pattern of spatial and temporal distribution of the enzyme that produces nitric oxide and correlate this pattern with periods of establishment and refinement of these projections during development. In several studies showed that the enzyme is present during development of topographic projections and their distribution is affected by intracellular electrical activity of afferent.

    Cell therapies in chronic degenerative diseases and traumatic injuries of the nervous system:

    More recently, our laboratory has initiated studies aimed at developing protocols for use of cell therapies in neurological diseases and injuries. With this in mind, two lines of research are under way: the study of the physiology of adult neural stem cells and research potential therapeutic stem cells of neural origin not in animal models of neurological diseases. The diseases we are investigating these animal models are: focal ischemia (as a model of ischemic stroke), global ischemia, spinal cord injury, and nerve injury perféricos. Still participate in phase I clinical study aimed at you assess the safety and feasibility of cell therapy with bone marrow stem cells in patients with ischemic stroke in the acute phase. Our lab is part of the Millennium Institute for Bioengineering and Tissue Cell Therapy Program at UFRJ.

Staff

Rosália Mendez Otero - Head of Laboratory

Marcelo Felippe Santiago

Pedro Moreno Pimentel Coelho  

Wagner Monteiro Cintra

Pos-Doctoral fellow

Fernanda Gubert Jasmin

Luiza Rachel Pinheiro de Carvalho

PhD Students

Alane Bernardo Ramos

Almir Jordão da Silva Junior

Andréa Marins Damasceno Bomfim

Elisa Nicoloso Simões Pires

Felipe Lopes Brum da Silveira

Ligia Lins de Castro

Louise Alessandra Mesentier Louro

Mariana Araya de Godoy

Michelle Bargas Rega

Master Students

Alvaro Carrier Ruiz

Gabriel Nascimento dos Santos

Undergraduated Students

Ana Beatriz Padilha de Figueiredo

Ana Luiza Bellot Decotelli Silva

Carlla Assis de Araújo e Silva

Carolina Viana Braga

Igor Bonacossa Pereira

Juliana Menechini Chan

Livian Rocha de Paula Silva

Luan Alves Tavares de Oliveira

Michelle Guimarães Furtado

Nicoli Cardoso Mortari

Renata Barros Leal

Soraia das Neves Vieira Cavalcanti

Technician

Felipe Melo Marins

Fernando C. Santana de Freitas

Suelen Soares Sério

 

 

 

Programa: 
Cellular Therapy and Bioengineering
Chefe do laboratório: